| 摘要 |
NEW MATERIAL:The compound of formula I (n is 6-10). EXAMPLE:6,6'-Di-O-decanoyl-alpha,alpha-trehalose. USE:An antitumor agent having extremely low toxicity. PREPARATION:For example, alpha,alpha-trehalose of formula II is converted to 2,3,2', 3'-tetra-O-benzyl-alpha,alpha-trehalose of formula III, which is made to react with preferably 1.8-2.4 times mole of a medium chain fatty acid (or its active derivative) of formula IV in the presence of an acid acceptor such as pyridine, triethylamine, etc. The resultant novel intermediate, 2,3,2',3'-tetra-O-benzyl-alpha,alpha-trehalose- 6,6'-(medium chain) fatty acid diester of formula V is reduced and debenzylated to obtain the objective compound.
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