发明名称 PRODUCTION OF STABILIZED INTERFERON PREPARATION
摘要 PURPOSE:An aminoacid or a combination thereof with human serum albumin is added to an interferon aqueous solution, then freeze drying is effected to produce the titled preparation having actions of inhibiting virus proliferation and resisting tumors. CONSTITUTION:An aminoacid or a combination thereof with human serum albumin is added to an interferon aqueous solution. Then, preferably the pH is adjusted to 7.1+ or -0.1 using hydrochloric acid or sodium hydroxide, in order to increase the stability of interferon. The resultant solution is freeze-dried to give the objective interferon preparation. The amount of the aminoacid added is preferably 0.05-0.3w/v%, while the amount of human serum albumin is preferably 0.01-1w/v%. When the resultant preparation is dissolved, the use of glucose aqueous solution or the addition of glucose to a solution of the interferon in a physiological salt solution enables the interferon to be kept stable, even after dissolving.
申请公布号 JPS59181224(A) 申请公布日期 1984.10.15
申请号 JP19830054495 申请日期 1983.03.29
申请人 SUMITOMO KAGAKU KOGYO KK 发明人 YAMAHIRA YOSHINARI;FUJIOKA TAKAHARU;SATOU SHIGEJI
分类号 C07K14/52;A61K38/21;C07K14/555;C07K14/57 主分类号 C07K14/52
代理机构 代理人
主权项
地址