发明名称 PROCESS FOR THE PREPARATION OF 3-(4-PHENYL BENZOYL)PROPIONIC ACID DERIVATIVES
摘要 Title compds. (I; R1=H, halogen, cyano, nitro, acyl; R2=H, halogen, C1-3 alkyl) useful as antiinflammatories, were prepd. by oxidation of II with Br,Cl,I in aq. alkali soln. II was prepd. by the reaction of III with IV in a halgenated hydrocarbon solvents in the presence of AlCl3. Thus, 15.4g biphenyl and 16.2g levulinic acid chloride were reacted in anhyd. Chloribenzene in the presence of anhyd. AlCl3 to give II. The reaction products(II), 33g NaOH and 48g Br were reacted at room temp for 3hr to give 22.4g 30(40phenylbenzoyl)-propionic acid.
申请公布号 KR840001656(B1) 申请公布日期 1984.10.12
申请号 KR19820004507 申请日期 1982.10.07
申请人 YU HAN CORP. 发明人 SOE JUNG-JIN;KIM SOK-HUN
分类号 C07C59/205;(IPC1-7):C07C59/20 主分类号 C07C59/205
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