| 摘要 |
NEW MATERIAL:A compound shown by the formula I (BX is residue obtained by removing hydroxyl group form carboxyl group of bleomycinic acid; R1 is lower alkyl; R2 is H, halogenobenzyloxy, lower alkoxy-benzyloxy, etc.; R3 is halogenobenzyloxy, lower alkoxybenzyloxy, etc.). EXAMPLE:3-{N-Methyl-N-[3'-(cyclotridecanylmethylamino)propyl]} aminopropylaminobleomycin. USE:A carcinostatic agent free from toxicity to the lung. PREPARATION:For example, an aminopropylaminobleomycin shown by the formula II is reductively condensed with a carbonyl compound shown by the formula R4-CHO(R4 is halogenobenzyloxy, benzyloxybenzyloxy, etc.) to give a compound shown by the formula I .
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