Antihypertensive benzopyrons.

摘要

Compounds formula (I):
<Chemistry id="chema01" num="0001"><Image id="ia01" he="43" wi="65" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein:
<UnorderedLists id="ula01" listStyle="none"><ListItem>one of R<Sub>1</Sub> and R<Sub>2</Sub> is hydrogen and the other is Ci-<Sub>6</Sub> alkyl-thiocarbonyl, C<Sub>1-6</Sub> alkoxy-thiocarbonyl, C<Sub>1-6</Sub> alkyl-thio- car- bonyloxy, 1-mercapto C<Sub>2-7</Sub>alkyl orformyl;</ListItem><ListItem>one of R<Sub>3</Sub> and R<Sub>4</Sub> is hydrogen or C<Sub>1-4</Sub> alkyl and the other is C<Sub>1-4</Sub> alkyl, or R<Sub>3</Sub> and R<Sub>4</Sub> together with the carbon atom to which they are attached are C<Sub>3-6</Sub> spiroalkyl;</ListItem><ListItem>R<Sub>5</Sub> is hydrogen, C<Sub>1-3</Sub> alkyl or C<Sub>1-8</Sub> acyl; and</ListItem><ListItem>n is 1 or 2; the lactam group being trans to the OR. group, having anti-hypertensive activity.</ListItem></UnorderedLists>