Cephalosporin compounds

摘要

Cephalosporin compounds represented by the general formula <IMAGE> (wherein R represents a group shown by formula <IMAGE> wherein R1 represents a hydrogen atom or a lower alkyl group of 1-3 carbon atoms and R2 represents a hydrogen atom, a lower alkyl group of 1-3 carbon atoms, a phenyl group which may be substituted by an amino or hydroxy group, a cyano group, a carboxy group, or a carboxymethyl group; said R1 and R2 may form a cycloalkylidene group of 4-6 carbon atoms together with the carbon atom to which they are bonded) or a group shown by formula -CH2-R3 (wherein R3 represents a hydrogen atom, a halogenomethyl group, a carbamoyl group, a carboxymethyl group, alpha 4-carboxy-3-hydroxyisothiazol-5-yl-thiomethyl group, or alpha 2-carboxyphenylthiomethyl group); R' represents a group shown by formula <IMAGE> (wherein Ra represents a carboxy group, a cyano group, or a carbamoyl group which may be substituted by a lower alkyl group of 1-3 carbon atoms and Rb represents a hydrogen atom or an amino group) or a group shown by formula <IMAGE> (wherein Ra and Rb have the same significance as above); and the waveline DIFFERENCE shows an anti-form or syn-form bond and the salts thereof. They possess excellent antibacterial activities against gram positive bacteria and gram negative bacteria, in particular, pseudomonas aeruginosa and are useful as anti-bacterial agents.