7-Oxabicycloheptane substituted thio prostaglandin analogs useful in treating platelet aggregation and bronchoconstriction

摘要

7-Oxabicycloheptane substituted thio prostaglandin analogs are provided having the structural formula wherein R is hydrogen, lower alkyl or alkali metal, R1 is lower alkyl, arylalkyl, aryl, cycloalkyl or cycloalkylalkyl. A is -CH=CH or -(CH2)2, n is 1 to 4, n' is 0 to 2 and m is 1 to 8, and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.