摘要 |
Renin-inhibiting tetra-, penta- or hexapeptide analogues of formula <MATH> where X and W are terminal groups; D, E, B and Z (of which any one or except with 'reduced' analogues any two may be absent) are aromatic, lipophilic or in the case of E aromatic lipophilic or basic amino acid or amino acid analogue residues; and A is an analogue of a lipophilic or aromatic dipeptide residue wherein the peptide link is replaced by a one- to four-atom carbon or carbon-nitrogen link which as such or in hydrated form is an unhydrolysable tetrahedral analogue of the transition state <CHEM> of the peptide bond. l |