| 摘要 |
Serine derivs (I; R=Ph. substituted Ph. tertiary alkyl hetero aromatic; R'=H, C1-4 alkyl; R'=H, Ph. C1-4 alkyl), used as anti-inflammatories, were prepd. by the hydrolysis of intermediate which reachted II and III in the presence of quaternary ammonium salt in strong inorganic acid. Thus, a solution of 60.4g p-nitrobenzaldehyde and 4.8g methyltributyl-ammonium chloride in 200ml CH2Cl2 was cooled at 5-7oC. 15g glycine and 8.8g NaOH was dissolved in 30ml H2O, stirred and added dropwise to CH2Cl2 for 4hr. The reactant was stirred further 3hr to give 1.6g threo-(P-nitrophenyl)serine hydrochloride.
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