发明名称 |
SYNTHESIS OF N-BENZYLOXYCARBONYL-1-ASPARTIC ACID |
摘要 |
N-Benzyloxycarbonyl-L-aspartic acid (Z-Asp) is synthesized by adding benzyl chloroformate to a solution of L-aspartic acid and sodium hydroxide at relatively high temperatures of 35 DEG -55 DEG C. and over a wide pH range of 9.2-12.0 and acidifying the sodium salt product. The Z-Asp is prepared in high yields exceeding 90% and purity of better than 99% with only a minor amount of the by-product N-benzyloxycarbonyl aspartyl aspartic acid. The Z-Asp is suitable for conversion to aspartame. Carrying out the reaction at high temperatures significantly reduces cycle time while maintaining a high yield with a low dipeptide and unreacted L-aspartic acid content. |
申请公布号 |
GB8421157(D0) |
申请公布日期 |
1984.09.26 |
申请号 |
GB19840021157 |
申请日期 |
1984.08.21 |
申请人 |
HATCO CHEMICAL CORPORATION |
发明人 |
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分类号 |
C07C271/22;A23L27/30;C07C67/00;C07C239/00;C07K5/075 |
主分类号 |
C07C271/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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