Prostaglandin E1 analogues

摘要

Prostaglandin E1 analogues of the general formula: <IMAGE> (wherein R1 represents a single bond or a straight- or branched-chain alkylene group of from 1 to 5 carbon atom(s), R2 represents a cycloalkyl group of from 4 to 7 carbon atoms either unsubstituted or substituted by at least one straight- or branched-chain alkyl group of from 1 to 8 carbon(s), and the double bond between C13 and C14 is trans) and cyclodextrin clathrate thereof, are useful in the prevention or treatment of cytodamage associated with digestive system disease, especially liver damage.