| 摘要 |
NEW MATERIAL:The compound of formula I (R<1>-R<4> are H or alkyl, or R<1> and R<2> may together with adjacent N atom form heterocyclic group; X is O, S or methylene; Z is O or S; m is 0 or 1; n is 2-4; p is 1 or 2), or its acid addition salt. EXAMPLE:3-Amino-4-5{2- [-( 3-pyrrolidino-1-propenyl )-2-thienylmethyl-thio ]ethylamino}-1,2,5-thiadiazole-1-oxide. USE:Drug for digestive organs and circulatory organs, and anti-inflammatory agent. PREPARATION:The objective compound can be prepared either by reacting the compound of formula II with the compound of formula III (L1 is halogen, lower alkoxy, or lower alkylthio) or by reacting the compound of formula II with the compound of formula IV and reacting the resultant compound of formula V with the compound of formula VI.
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