发明名称 |
Use of nafazatrom as lipoxygenase inhibitor, in the therapy of cardiac dysrhythmias and ischaemias, and of rheumatic, allergic and asthmatic disorders, oedemas, pulmonary embolisms, pulmonary hypertension, oxygen intoxication and ulceration, pharmaceutical compositions for this purpose, and process for the production thereof |
摘要 |
The present invention relates to the use of 3-methyl-1-[2-(2-naphthyloxy)ethyl]-2-pyrazolin-5-one ("nafazatrom") as lipoxygenase inhibitor, for preventing and treating ischaemias, especially myocardial infarcts following myocardial ischaemias, cardiac dysrhythmias, rheumatic, allergic and asthmatic disorders, pulmonary embolisms and oedemas (especially pulmonary oedemas), pulmonary hypertension, oxygen intoxication and ulceration. The invention also relates to lipoxygenase-inhibiting, bronchodilating, antiarrhythmic, antiischaemic, antirheumatic, antiallergic, antiasthmatic, antioedemic, antihypertensive and gastroprotective pharmaceutical compositions which are characterised by containing a therapeutically effective amount of nafazatrom.
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申请公布号 |
DE3308880(A1) |
申请公布日期 |
1984.09.20 |
申请号 |
DE19833308880 |
申请日期 |
1983.03.12 |
申请人 |
BAYER AG, 5090 LEVERKUSEN, DE |
发明人 |
MARDIN, MITHAT, DIPL.-CHEM. DR.;SEUTER, FRIEDEL, DIPL.-BIOL. DR.;BUSSE, WOLF-DIETER, DIPL.-CHEM. DR.;PERZBORN, ELISABETH, DIPL.-BIOL. DR.;HOFFMEISTER, FRIEDRICH, PROF. DR.;FIEDLER, VOLKER, DR.;SCHLOSSMANN, KLAUS, DIPL.-CHEM. DR., 5600 WUPPERTAL, DE;MAYER, DIETER, PROF. DIPL.-CHEM. DR., 4712 WERNE, DE |
分类号 |
A61K31/415;(IPC1-7):A61K31/41 |
主分类号 |
A61K31/415 |
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