| 摘要 |
PURPOSE:To obtain a physiologically active substance having an inhibitory action on cholesterol synthesis, by cultivating a specific microorganism belonging to the genus Trichoderma or Eupenicillium, collecting ML-236B from the culture. CONSTITUTION:A microorganism belonging to the genus Trichoderma or Eupenicillium, capable of producing ML-236B, is cultivated aerobically, and physiologically active substance ML-236B shown by the formula is collected from the culture. Trichoderma viride IFO5836, Eupenicillium reticulisporum strain, its variant or mutant may be cited as the microorganism producing ML-236B to be used. A strain capable of producing ML-236B is cultivated aerobically by mold culture, and ML-236B is produced in the culture. For example, the strain capable of producing ML-236B is subjected to subculture in a medium consisting of 2wt% malt extract, 2wt% glucose, 1wt% peptone and 2wt% agar. |
