Process for preparing a beta-(fluoroalkyl or fluoroalkenyl)-beta-hydroxyalkyne and an alpha-(fluoroalkyl or fluoroalkenyl)-allyl alcohol thereof.

摘要

A process for preparing a beta -(fluoroalkyl or fluoroalkenyl)- beta -hydroxyalkyne represented by the formula (I) wherein Rf represents a fluoroalkyl or fluoroalkenyl group and R represents an aliphatic or aromatic group, comprising reacting an alkyne represented by the formula R-C 3BOND CH (II) wherein R is the same as defined above with a fluorine containing aldehyde represented by the formula RfCHO (III) wherein Rf is the same as defined above in the presence of catalyst under ultrasonic irradiation. A process for preparing an alpha -(fluoroalkyl or fluoroalkenyl)allyl alcohol represented by the formula (IV) wherein Rf represents a fluoroalkyl or fluoroalkenyl group, R represents an aliphatic or aromatic group and R' represents a hydrogen atom or an aliphatic group, comprising (1) reacting a beta -(fluoroalkyl or fluoroalkenyl)- beta -hydroxyalkyne represented by the formula (I) wherein Rf and R are respectively the same as defined above with a isobutylmagnesium halide represented by the formula i-C4H9MgX wherein X represents a halogen atom, and (2) reacting the reaction mixture thus obtained above with a halide represented by the formula R'X' wherein X' represents a halogen atom and R' is the same as defined above.