发明名称 |
N-Methanesulfonic acid derivatives of 3-O-demethylistamycin B and production thereof |
摘要 |
New semi-synthetic antibiotic derivative are formed from N-methanesulfonic acid derivatives of 3-O-demethylistamycin B which are less toxic than the parent 3-O-demethylistamycin B and retain usefully high antibacterial activity of the parent antibiotic. The new derivatives are produced by a method of N-sulfomethylation where 3-O-demethylistamycin B is reacted with an aldehyde such as paraformaldehyde and sulfurous acid or sulfite reagent.
|
申请公布号 |
US4472388(A) |
申请公布日期 |
1984.09.18 |
申请号 |
US19830458824 |
申请日期 |
1983.01.18 |
申请人 |
MICROBIAL CHEM RES FOUND |
发明人 |
UMEZAWA, HAMAO;KONDO, SHINICHI |
分类号 |
A61K31/70;A61K31/7028;A61K31/7034;A61K31/7036;A61P31/04;C07H15/224;(IPC1-7):A61K31/70;C07H15/22 |
主分类号 |
A61K31/70 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|