发明名称 |
SETT ATT FRAMSTELLA OPTISKT AKTIVA ELLER RACEMISKA LAKTONDIOLDERIVAT SAMT LAKTONDIOLDERIVAT TILL ANVENDNING SOM MELLANPRODUKTER VID FRAMSTELLNING AV PROSTAGLANDINER OCH PYRETROIDER |
摘要 |
The invention 1s concerned with a novel process for producing compounds of formula 1 I wherein R3 and R4 are the same or different and each represent hydrogen or a lower alkanoyl group whlich is unsubstituted or is substituted by one, two or three halogen atoms, or R3 and R4 together form a qroup R5-?-R6 wherelin R5 and R6 are the same or different and each represent hydrogen or a methyl or phenyl group, with the proviso that when one of R5 and R6 is phenyl the other is hydrogen. The compounds of formula I are obtained by reacting a lactone of formula II II with formaldehyde or a polymer of formaldehyde in the procence of a strong acid, followed, if necessary, by reaction with a compound of formula R5COR6 or R5CHO or an acetal thereof. The compounds of formula I are useful lntermediates in Corey's synthesis of prostaglandins and those compounds in which R3 and R4 form a group ,5-?-R are novel. |
申请公布号 |
SE435282(B) |
申请公布日期 |
1984.09.17 |
申请号 |
SE19770001666 |
申请日期 |
1977.02.15 |
申请人 |
CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT |
发明人 |
1)I * TOMOSKOZI;2)G * KOVACS;3)I * SZEKELY;4)V * SIMONIDESZ;5)M * LOVASZ;6)B * KERESZETS;7)J * REMPORT;8)I * STADLER;9)Z * VISKY;10)C * SZANTAY |
分类号 |
C07D307/93;A61K31/34;A61K31/343;A61P43/00;C07D307/935;C07D493/04;(IPC1-7):07D307/935;07D493/04 |
主分类号 |
C07D307/93 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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