| 摘要 |
PURPOSE:A biosynthetic inhibitor for fatty acids, containing a specific dicarboxylic acid as an active constituent, and capable of inhibiting acetyl CoA carboxylase and treating obesity due to excess fat causing arteriosclerosis, diabetes, etc. CONSTITUTION:A biosynthetic inhibitor for fatty acids containing a dicarboxylic acid of the formula (R is alkyl or alkenyl; n is 0 or an integer 1-6), anhydride or a salt thereof as an active constituent. The compound of the formula is capable of inhibiting acetyl CoA carboxylase which is a rate determining enzyme of a synthetic system for the fatty acids. Thus, the accumulation of excess fat which is a direct or indirect cause for arteriosclerosis, diabetes or gout, etc. having a tendency to cause complication is inhibited. The above-mentioned inhibitor can be orally or parenterally administered. The daily dose thereof is usually 0.1-2,000mg/kg. The compound of the formula can be produced by the well-known method.
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