| 摘要 |
NEW MATERIAL:A compound shown by the formula I (R<1> is H, or OH; X is halogen). EXAMPLE:1-beta-D-Aravinofuranosyl-5-(2-bromo-2-carboxyvinyl) uracil. USE:An intermediate for synthesizing an antiviral compound. PREPARATION:A 5-formyluracil nucleoside shown by the formula II is reacted with a phosphorane shown by the formula III (R<2> and R<3> are alkyl or aryl) to give a 5-(2-alkoxy or aloxycarbonyl-2-halogenovinyl)uracil nucleotide shown by the formula IV. This compound is then hydrolyzed in a water using an alkali or a water-containing solvent at 0 deg.C- room temperature for several hours.
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