| 摘要 |
PURPOSE:To obtain the titled compound without preparing an oily substance, by using an aqueous medium having a specific concentration, adding CO2 and ammonia in a specific molar range to it to form a reaction solvent system, reacting it with a substituted benzaldehyde cyanohydrin which is added dividedly. CONSTITUTION:In preparing a hydantoin shown by the formula IV by reacting a substituted benzaldehyde cyanohydrin shown by the formula I (X is H, OH, alkyl, alkoxy, or halogen)(S-BCH for short) with CO2 and ammonia, 5-35wt% uniform aqueous solution of alcohol, ether, alcohole-ether, or ketone (e.g., methanol, etc.) miscible with water is used as a reaction solvent, CO2 and ammonia are added to the solvent in such a way that the relationship shown by the formula II and formula III are satisified. The reaction is carried out by adding S-BCH dividedly, to give the desired compound shown by the formula IV without preparing an oily or tarry substance. USE:An intermediate raw material for D-form substituted phenylglycine.
|
