| 摘要 |
PURPOSE:The titled composition that is composed of freeze-dried peptide hormones and a water-absorbing base and adjusted in particle sizes to a specific level, thus distributing widely in the nasal cavities with high residence time to be absorbed effectively through nasal mucosa. CONSTITUTION:The objective composition is composed of freeze-dried peptide hormones such as calcitonin, vasopressin, insulin or interferon and a water- absorbing base, preferably a starch, such as dextrin, cellulose such as carboxymethylcellulose, saccharide such as lactose, vinyl polymer such as cross-linked polyacrylate salt and is a powder of which more 90% have particle sizes of 10- 250, preferably 20-150mic. When the dust is sprayed in a nose, the compositon stays without increase in nasal mucus to absorb the liquid excreted by the nasal mucous membranes, swells until dissolving, thus the peptide hormone is released to keep the concentration of the drug high at local sites.
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