摘要 |
PURPOSE:To prepare a specific beta-methyl alpha-hydroxyester, by contacting a specific compound with microorganism belonging to Candida genus, Endomycopsis genus, etc. or its cell. CONSTITUTION:A beta-methyl alpha-hydroxyester of formula II (R is alkyl) is prepared contacting the compound of formula I (R is defined above) with microorganism or its cell selected from the group of Candida genus, Endomycopsis genus, Hansenula genus, Kloeckera genus, Lipomyces genus, Pichia genus, Rhodotorula genus Saccharomyces genus. The obtained substance is useful as an important intermediate for the synthesis of erythromycin having strong antibacterial activity against e.g. Gram-positive bacteria and low toxicity and useful as a remedy for bacterial infectious diseases. It is also useful as an important intermediate for the synthesis of oudemansin which is an antibiotic having strong antibacterial activity and exhibiting the activity to inhibit the synthesis of nucleic acid in Ehrlich ascites carcinoma cell. |