DIHYDROPYRIDINE ANTI-ISCHAEMIC AND ANTIHYPERTENSIVE AGENTS

摘要

1,4-Dihydropyridine derivatives of the formula: wherein R is aryl or heteroaryl; R1 and R2 are each C1-C4 alkyl or 2-methoxyethyl; n is 2, 3 or 4; R3 is H, C1-C4 alkyl, CH2CO2(C1-C4 alkyl) or CH2CN; and R4 is a group of the formula COR5, CSR5, C(=NR6)R7 or SO2R5, wherein R5 is C1-C4 alkyl, NH2, NH(C1-C4 alkyl), NH(C3-C6 cycloalkyl), N(C1-C4 alkyl)2, NHCH2CO2(C1-C4 alkyl), NHCH2CONH2, NHCH2CO2H, NH(CH2)2NH2, NHNH2, NHNRCO2(C1-C4 alkyl), NH-aryl, NHCO-aryl or a heterocyclic, NH-heterocyclic or NHCO-heterocyclic group, or when R4 is C(=O)R5, R5 may be H or CF3; R6 is H, CN, CO2(C1-C4 alkyl), CO(C1-C4 alkyl), SO2(C1-C4 alkyl), SO2-aryl, SO2NH2, SO2N(C1-C4 alkyl)2, NO2 or aryl; and R7 is NH2, NH(C1-C4 alkyl), NHCO(C1-C4 alkyl), NH(CH2)mN(C1-C4 alkyl)2 wherein m is 2 to 4 or a NH-heterocyclic group; and their pharmaceutically acceptable acid addition salts, and pharmaceutical preparation containing such compounds, have utility as anti-ischaemic and antihypertensive agents.