1,4-Dihydropyridine compound.

摘要

1,4-Dihydropyridine compound having the general formula: <CHEM> wherein R is 2-(5,6-dihydro-p-dioxinyl), 2-(3,5-dimethyl-5,6-dihydro-p-dioxinyl), 2-(3-methyl-5,6-dihydro-p-dioxinyl), 2-(3-methoxymethyl-5,6-dihydro-p-dioxinyl), 5-(3,4-dihydro-2H-pyranyl), or 2-(5,6-dihydro-1,4-dithiinyl); R<1> and R<2> are independently a cyano group, an acetyl group, or a substituted oxycarbonyl group having the general formula COOR<4> wherein R<4> is a methyl, isopropyl, allyl, propargyl, methoxymethyl, 2-methoxymethyl, or 1-methyl-2-methoxymethyl group provided that both R<1> and R<2> are nor -COOCH3 in the case of R being 2-(5,6-dihydro-p-dioxinyl) and R<3> being hydrogen; and R<3> is hydrogen or a methoxymethyl group. This 1,4-dihydropyridine compound has a remarkable liver protective action and a low toxicity.