Immunostimulatory dipeptidyl D-glucose derivatives and methods of preparation.

摘要

Compounds of the general formula: <CHEM> wherein R1, R2 and R3 are independently H or -@CH3; R4 is -@CH3 or an acoxycarbonyl group of the formula: -C@-O-R10 wherein R10 is C1-50 alkyl; 1- or 2-adamantyl; or 3-cholesteryl; R<5> is H or C1-10 alkyl; provided that when R5 is C1-10 alkyl, the stereochemistry at chiral center I is either D or L; R6 is H or R6-R7 together is -CH2-CH2-CH2-; R7 is H, C1-7 alkyl, hydroxymethyl, mercaptomethyl, benzyl or p-hydroxybenzyl; provided that when R7 is not H, the stereochemistry at chiral center II is L; R8 and R9 are independently -COOR or -CONR min R sec wherein R is H or C1-7 alkyl, and R min and R sec are independently H or C1-3 alkyl; the stereochemistry at chiral center III is always D. These compounds possess adjuvant and immunostimulatory properties.