| 摘要 |
<p>PURPOSE:To obtain the titled compound which is an antibiotic substance for plants, by protecting the NH2 group of a specific adenosine derivative which is a starting raw material, and reacting the resultant compound with tert- butyloxycarbonyl-L-alanylimidazole and removing the protecting group. CONSTITUTION:2-Chloro-9-( 2', 3'-O-isopropylidene-5'-O-sulfamoyl-beta-D-ribofuranosyl) adenosine which is a starting raw material expressed by formula I is first reacted with di-tert-butyl bicarbonate, preferably at -78-+100 deg.C reaction temperature for 1-20hr reaction time to give a compound expressed by formula II (BOC is tert-butyloxycarbonyl), which is then subjected to coupling reaction with tert-butyloxycarbonyl-L-alanylimidazole to form a compound expressed by formula III. The resultant compound expressed by formula III is then treated with an acid, preferably trifluoroacetic acid to remove the protecting group and afford the aimed compound expressed by formula IV. The treatment with the acid is preferably carried out at -78-+100 deg.C for 0.5-20hr.</p> |
