| 摘要 |
Anilinoimidazolines(I; R1=substituted aryl; R2, R3=H, halogen alkyl, alkoxy, alkanesulfonamido, halozlkyl, carbamoyl, NO2, amino, cyano, SO2NH2; A=O, CH2; N=1-2), used as antihypertensive, anti-inflammatory, analgesia, were prepd. by the reaction of VI and VII. In an example, 2-chloro-2-imida-zolinesulfate(1g) in 5% 10ml NaOH was extracted by methyene chloride. A mixt. of 0.91g 2-(3, 4, 5-trimethoxyphenoxy)-aniline with methylenchloride was stirred at room temp. for 42hr. The product 2-[2(3, 4, 5-trimethoxyphenoxy) phenyl amino-2-imidazoline was purified by recrystallization from ethylace-tate gave 0.3g white powder. (m.p 156-159≦̸C). |
