发明名称 |
DIOXOLANE DERIVATIVES FOR USE AS CHEMICAL INTERMEDIATES |
摘要 |
The invention is concerned with novel dioxolane derivatives of the formula: <IMAGE> I in which Ra is hydrogen or (1-4C)alkyl and Rb is (1-4C)alkyl or phenyl optionally bearing a halogeno substituent; their production; and their use for the manufacture of certain known anti-arthritic acids of the formula: <IMAGE> V and, in particular, those acids in which Ra=Rb=methyl or Ra=ethyl and Rb=phenyl, by a novel reduction process. The preferred reduction procedures involve the use of an alkali metal borohydride or cyanoborohydride in the presence of a noble metal catalyst, or the use of an alpha -branched alkyl or cycloalkyl Grignard agent. The use of the derivatives of formula I avoids the need for potentially toxic reagents and reactive intermediates in the previously known processes for the production of the acids of formula V. |
申请公布号 |
DE3165174(D1) |
申请公布日期 |
1984.09.06 |
申请号 |
DE19813165174 |
申请日期 |
1981.03.31 |
申请人 |
IMPERIAL CHEMICAL INDUSTRIES PLC |
发明人 |
EDWARDS, PHILIP NEIL;MARTIN, DAVID MICHAEL GLANVILLE |
分类号 |
C07C45/49;C07C59/66;C07D317/34;(IPC1-7):C07D317/34 |
主分类号 |
C07C45/49 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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