| 摘要 |
PURPOSE:To obtain the titled compound useful as an intermediate for preparing perfume, cosmetic base, etc. easily in high yield, by using a specific sulfur- containing homoallyl alcohol as a raw material, oxidizing it to give a sulfoxide, reacting it under heating. CONSTITUTION:An allyl Grignard reagent shown by the formula I (R<1>-R<3> are H, alkyl, cycloalkyl, alkenyl, or aryl; X is Cl, Br, or I) is reacted with alpha-thioketone shown by the formula II [R<5> is alkyl, or aryl; R<6> is R<5>, or group shown by the formula III (R<7> is H, or alkyl; R<8>=R<5>)] to give a sulfur-containing homoallyl alcohol shown by the formula IV in high yield. The alcohol is oxidized with an oxidizing agent such as preferably m-perchlorobenzoic acid, etc. at -30-50 deg.C to give a sulfoxide, which is reacted under heating at 100-600 deg.C in a liquid phase or gaseous phase to give a delta, epsilon-unsaturated ketone shown by the formula V(R<4> is as shown for R<6> when R<6> of the formula II is R<5>, or group shown by the formula VI when R<6> is group shown by the formula III). USE:An intermediate for preparing drugs, agricultural chemicals, etc.
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