| 摘要 |
<p>New nitrosoureas, their preparation and application in therapy, consisting of compounds having the formula (I), of the series L, D, DL, allo and threo, wherein: A represents the fragment of an amino acid having the formula HN(R)-A-COOH, wherein R is a hydrogen atom, an organic radical particularly an alkyl radical, or forms together with the nitrogen atom and A a heterocycle; Y is a nitrosourea radical having the formula (II) and X is a nitrogen mustard radical having the formula Cl-CH2-CH2-MH-, (Cl-CH2-CH2)2N- or (Cl-CH2-CH2)2N-C6H4-NH-. Application to the treatment of tumors.</p> |
