| 摘要 |
<p>PURPOSE:To obtain the titled compound useful as an intermediate for synthesizing cephem antibiotics in high yield, by reacting a 3-methyl-DELTA<2>-cephem derivative with an N-halosulfoximine. CONSTITUTION:A 3-methyl-DELTA<2>-cephem derivative shown by the formula I (R<1>CO is organic acyl; R<2> is H, or carboxyl-protecting group) is reacted with an N- halosulfoximine(e.g., N-halo-phenylmethysulfoximine, etc.) shown by the formula II[R<3> and R<4> are 1-6C alkyl, 5-6C cycloalkyl, (substituted) aryl, or aralkyl; X is chlorine, bromine, or iodine], to give the disired compound shown by the formula III.</p> |
