摘要 |
PURPOSE:To obtain an N<6>,2'-O-diacyladenosine-3',5'-cyclic phosphate useful as a drug and a reagent advantageously, by reacting adenosine-3',5'-cyclic phosphoric acid with a carboxylic acid anhydride in the presence of a tertiary amine under heating, treating the resultant product with a salt exchanging agent. CONSTITUTION:Adenosine-3',5'-cyclic phosphoric acid is reacted with preferably 3-6 times the molar quantity of carboxylic acid anhydride(e.g., acetic anhydride, etc.) in the presence of preferably 1-3 times the molar quantity of a tertiary amine under heating to form N<6>,2'-O-diacyladenosine-3'5'-cyclic phosphoric acid (DBc-AMP for short), which is treated with a salt exchanging agent (e.g., NaH CO3, etc.), to give an alkali metal salt of DBc-AMP. EFFECT:The desired compound can be prepared efficiently, economically and in high yield.
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