| 摘要 |
PURPOSE:To prepare the titled compound useful as a starting substance for the synthesis of nucleic acid in genetic engineering, easily, by reacting a nucleoside with a bifunctional silicon compound in the presence of a base, reacting the product with an organic carboxylic acid halide, and hydrolyzing the product. CONSTITUTION:A nucleoside is made to react the a bifunctional silicon compound of formula (R<1>-R<4> are alkyl or phenyl; X is halogen; n is 0 or 1) in the presence of a base (preferably pyridine) to protect two hydroxyl groups at the deoxyribose segment of said nucleoside. The obtained reaction product is made to react with an organic carboxylic acid halide (e.g. benzyl chloride, anisoyl chloride, etc.) and hydrolyzed to obtain the objective N-acylated nucleoside.
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