| 摘要 |
NEW MATERIAL:The compound of formula I (R<1> is H or amino-protecting group; R<2> is omega-carboxyl-protecting group; R<3> is alpha-carboxyl-protecting group). USE:Synthetic intermediate of decapeptide, useful as a substance for investigating carcinogenic mechanism. It has antagonistic inhibiting activity against the carcinogenic protein produced by carcinogenic gene of avian sarcoma virus. PREPARATION:The compound of formula I can be prepared by reacting the glutamic acid derivative of formula II (R<1>' is amino-protecting group) with the tripeptide derivative of formula III in the presence of a condensation agent (e.g. dicyclohexylcarbodiimide, Woodward reagent, etc.) in a solvent such as hexamethylphosphoramide, tetrahydrofuran, etc. at 0-50 deg.C. If necessary, the protecting group of the alpha-amino group is removed.
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