| 摘要 |
PURPOSE:In an aqueous pharmaceutical preparation containing a main drug and cyclodextrin, the pharmaceutical preparation having the stabilized main drug and improved solubility, containing a specific phenolic derivative as a preservative. CONSTITUTION:In an aqueous pharmaceutical preparation containing a main drug and cyclodextrin, the preparation containing a compound shown by the formula (R is alkyl; X is halogen; n is 0-2; m is 0-3). Generally a drug having high hydrophilic nature and low distribution ratio of oil and water has low absorption properties, it is blended with dextrin to improve absorption properties, to stabilize the main drug, and to improve solubility, and it contains a preservative. But some of aqueous pharmaceutical preparation have reduction in preserving effect of the preservative. When the phenolic derivative is used as the preservative, reduction in antimicrobial power, precipitation of insoluble complex, etc. caused by interaction with cyclodextrin are not observed, and reduction in preserving effect will not occur. A concentration of the preservative added is preferably about 0.01-1%(w/v).
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