Methods and materials for development of parvovirus vaccine.

摘要

Novel immunologically active polypeptides for use in anti-parvovirus vaccines are provided through structural analysis and characterization of the parvovirus genome. In a preferred embodiment, microbial expression of polypeptides is secured through use of DNA vectors comprising DNA sequences duplicative of porcine parvovirus (PPV) genomic DNA. Microbially expressed polypeptides as well as synthetic replicas of polypeptides coded for by DNA sequences of the invention exhibit immunological activity in, e.g., plate binding assays.