发明名称 New aryloxypropanolamine derivatives, process for the preparation thereof, pharmaceutical compositions and therapeutic use.
摘要 <p>Compounds having general formula I &lt;Chemistry id="chema01" num="0001"&gt;&lt;Image id="ia01" he="34" wi="96" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /&gt;&lt;/Chemistry&gt;wherein &lt;UnorderedLists id="ula01" listStyle="none"&gt;&lt;ListItem&gt;R&lt;Sub&gt;1&lt;/Sub&gt; is hydrogen, lower alkyl, lower alkoxy, alkylenoxy, halogen, cyano, carboxyamido or ureido group optionally separated from the phenyl ring by a methylene or ethylene bridge;&lt;/ListItem&gt;&lt;ListItem&gt;R&lt;Sub&gt;2&lt;/Sub&gt; is hydrogen, halogen, lower alkyl or alkoxy;&lt;/ListItem&gt;&lt;ListItem&gt;R&lt;Sub&gt;3&lt;/Sub&gt; is hydrogen, halogen, lower alkyl, lower alkoxy or R&lt;Sub&gt;2&lt;/Sub&gt; and R&lt;Sub&gt;3&lt;/Sub&gt;, taken together, are a methylendioxy group;&lt;/ListItem&gt;&lt;ListItem&gt;R&lt;Sub&gt;4&lt;/Sub&gt; is hydrogen or lower alkyl, endowed with remarkable cardioselective β-adrenolytic properties, are described.&lt;/ListItem&gt;&lt;/UnorderedLists&gt;</p><p>The process for their preparation and pharmaceutical compositions containing them are also described.</p>
申请公布号 EP0116825(A1) 申请公布日期 1984.08.29
申请号 EP19840100085 申请日期 1984.01.06
申请人 PIERREL S.P.A. 发明人 CASAGRANDE, CESARE;NICOLA, MASSIMO
分类号 A61K31/415;A61K31/4166;A61P9/00;A61P9/06;A61P9/08;A61P9/10;A61P25/02;C07D233/72;C07D303/22;C07D405/04;(IPC1-7):07D233/72;61K31/415;07D405/04 主分类号 A61K31/415
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