SUBSTITUTED PIRROLIDINYL-BENZOIC ACID DERIVATIVES AND A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL FORMULATION

摘要

What are disclosed are pyrrolidinylsulfamoylbenzoic acid compounds of the formula in which R1 and R2 denote C1-C4alkyl and one of the radicals R1 or R2 may be hydrogen, R3 and R3' denote hydrogen or C1-C4alkyl or together denote a C-C linkage, R4 and R4' denote hydrogen, halogen, CF3, alkyl or C1-C2alkoxy, hydroxy, amino or dimethylamino in the various positions of the aryl nucleus, or together denote 3,4-methylenedioxy, R5 and R6 denote hydrogen, C1-C4alkyl or benzyl, Ar denotes phenyl or a 5-membered or 6-membered heteroaromatic ring containing a O, S or N atom and X is omitted or denotes oxygen, sulfur, NH, or CH2, and their pharmaceutically acceptable salts with bases or acids. The compounds and salts have a salidiuretic action and can be used for the treatment of edematous diseases.