发明名称 |
E - 5 - (2-HALOGENOVINYL) - 2' - DEOXYCYTIDINES |
摘要 |
<p>E-5-(2-haloqenovinyl)-2'-deoxycytidines The invention relates to E-5-(2-halogenovinyl)-2'-deoxycytidines, e.g. E-5-(bromovinyl)-2'-deoxycytidine and E-5-(2-iodovinyl)-2'-deoxycytidine. These substances are endowed with specific antiviral activities towards herpes simplex virus and with an extremely low toxicity which makes them useful in antiviral medicines and for treatment of virus diseases in man and animal. They may be synthesised by introduction of an E-5-(2-halogenovinyl) sidechain into 2'-deoxycytidine, or by condensation of a trialkylsilyl derivative of E-5-(2-halogeno-vinyl)-cytosine with a hydroxyl-protected reactive derivative of 2'-deoxy-D-erythro-pentofuranose.</p> |
申请公布号 |
CA1173438(A) |
申请公布日期 |
1984.08.28 |
申请号 |
CA19800361953 |
申请日期 |
1980.10.03 |
申请人 |
UNIVERSITY OF BIRMINGHAM (THE);STICHTING REGA V.Z.W. |
发明人 |
JONES, ALBERT S.;WALKER, RICHARD T.;DE CLERCQ, ERIK;VERHELST, GABRIEL A. |
分类号 |
C07H19/073;A61K31/70;A61K31/7042;A61K31/7052;A61K31/7064;A61K31/7068;A61P31/12;C07H19/06;(IPC1-7):C07H19/06 |
主分类号 |
C07H19/073 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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