| 摘要 |
PURPOSE:To prepare the titled compound useful as an intermediate of pharmaceutical or agricultural chemicals, optical resolving agent, etc., by the optical resolution of dl-2,2-dimethylcyclopropanecarboxylic acid using an optically active phenylamine as the optical resolving agent. CONSTITUTION:The objective compound is obtained by (1) reacting dl-2,2-dimethylcyclopropanecarboxylic acid with an optically active phenylethylamine of formula (R1 and R2 are H or lower alkyl) (e.g. d-alpha-phenyl-beta-phenylethylamine) in a solvent to form a diastereomer salt, (2) cooling the reaction mixture slowly to precipitate one of the optically active diastereomer salts, and (3) separating and decomposing the precipitated salt. EFFECT:The used optical resolving agent can be recovered and reused. USE:Reagent for determination of the optical purity of an optically active amine.
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