| 摘要 |
The invention relates to producing lyophilized, adsorbed, polyvalent vaccines. According to the invention, tetanus, diphtheria, pertussis and, where appropriate, typhus antigens, which have been concentrated to 5 to 15 doses/3 ml, are adsorbed, at a pH of from 3 to 6, onto an insoluble support, which has been concentrated in the same manner as the antigens, after which the pH of the mixture is adjusted to 5 to 6 and it is lyophilized together with a protective material which is normally used in lyophilizing processes. Before administration, the lyophilized vaccine is diluted to the required concentration using a physiological salt solution which has been buffered with a phosphate solution to a pH of 6.8 to 7. |
