| 摘要 |
The hydantoins of formula (I) and their esters, amides, salts and soivates have prostaglandin mimetic and antagonistic properties rendering them useful in medicine. In formula (I) <CHEM> Z is hydrogen or alkyl; Z<1> represents a group of formula -CH2-X-X<1>-X<2> wherein, X is selected from -(CH2)2- and cis and trans -CH=CH-, X<1> is a covalent bond or a straight or branched alkylene chain having 1 to 6 carbon atoms optionally having one of its methylene groups replaced by oxa (-O-) or thia (-S-) provided that at least one carbon atom separates the oxa or thia group from a carboxyl or -CH=CH- group, and X<2> is a carboxyl group; and Z<2> represents a group selected from -NH-CH2-R and -N=CH-R wherein, R is a group selected from -CO-Y and -@@-Y, Y being a group selected from C3-8 alkyl, C3-8 alkenyl, phenyl-C1-4 alkyl and phenyl (wherein the phenyl group in both cases is optionally substituted by one or more groups independently selected from alkyl, alkoxy, nitro, halo and trihalomethyl), cycloalkyl of 4 to 8 carbon atoms, and 5- or 6-membered heterocyclic radicals containing at least one heteroatom selected from oxygen, sulphur and nitrogen; and Y<1> being a group selected from hydrogen, hydroxy, alkoxy and acyloxy. |
