3,4-DISUBSTITUTED 1,2,5-OXADIAZOLE 2-OXIDES, PROCESSES FOR THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM

摘要

3,4-Disubstituted 1,2,5-oxadiazole 2-oxides of the formula I (I) wherein, when R2 represents CH3, R1 denotes -CONHR3NR24, -CONHR3OR7, -CONHCH2CH=CH2, -CONHR8, -CONR9R10, -CONHR11CO2R4, -CONHR11CONH?2, -CONHR11-Het, , -CONHR11CONHR8, and when R2 is other than CH3 and has one of the meanings indicated above for R1, R1 denotes -CH3, R3 denotes an alkylene radical -CnH2n-, wherein ?? 2, 3 or 4, R4 denotes -CH3 or -C2H5, R5 and R6 denote -H, -CH3, -C2H5, -OCH3 or Cl, R7 denotes -H, -CH3 or -C2H5, R8 denotes C1-C6 alkyl or C3-C7 cycloalkyl, R9 and R10 denote C1-C4 alkyl, R11 denotes an alkylene radical -CmH2m wherein m = 1, 2 or 3, Het denotes a pyridyl, pyrimidinyl, thienyl, oxazolyl, imidazolyl, furanoyl or thiazolyl radical, X denotes -(CH2)p-, -(CH2)2-0-(CH2)2- or and R2 denotes -CH3 and, when R1 denotes -CH3, R2 has one of the meanings indicated for R1, with the exception of -CH3, and pharmacologically acceptable acid addition compounds thereof. These compounds may be used for curing, or preventing cardiovascular system diseases, such as antihypertensives.