Preparation of 1,1,1,3,3,3-hexafluoropropane-2-ol by vapor phase catalytic reaction of hexafluoroacetone hydrate with hydrogen

摘要

1,1,1,3,3,3-hexafluoropropane-2-ol is obtained with high yield and high selectivity by vapor phase hydrogenolysis of a hydrate of hexafluoroacetone by using either a nickel catalyst or a palladium catalyst, or both. Hydrates of hexafluoroacetone are convenient to handling and storage because of being liquid or solid at room temperature and, moreover, can be refined to extremely high purity so that the catalyst exhibits long service life without suffering from poisoning. The hydrogenolysis reaction takes place at relatively low temperatures such as 40 DEG -200 DEG C. at atmospheric pressure.