| 摘要 |
<p>Novel bicyclooctane compounds of the general formula: <CHEM> wherein R1 is a hydrogen atom or a C1-C4 alkyl group, R2 is a hydrogen atom or a C1-C5 alkyl group, A is a C1-C10 alkylene group, B is a direct bond, a cycloalkylene, or a group of one of the formulae: -O-, -CH=CH-, -C IDENTICAL C-, <CHEM> (o, m, p-phenylene or phenoxylene), D is a C1-C5 alkylene or a cycloalkylene group, X is an ethylene, a vinylene or an ethynylene group, Y1, Y2 and Y3 are each independently a free or a protected hydroxy group or a pharmaceutically acceptable salt of such a compound wherein R is a hydrogen atom and their pharmaceutically acceptable salts, and their production and use. The compounds have potent platelet antiaggregation activity and hypotensive activity and are useful in treating and preventing thromboses and in treating hypertension, and the compounds have also potent antisecretory and antiulcerogenic activity and are useful in treating and preventing gastrointestinal ulcer.</p> |
