ANTI-INFLAMMATORY METHODS AND COMPOSITIONS

摘要

RAN 4070/61 Inflammation of dermal tissues can be treated by topically administering to the affected area an effective amount of a compound of the formula I wherein X is -S- or -O-; Y is -CH=, -CH2- or -N=; R is lower alkyl or hydroxy-lower alkyl; R' is lower alkyl, halo, cyano, lower alkylthio, carboxy or lower alkylcarboxy; and z is zero or 1; provided that when Y is -CH2-, R' is bromo and X is -S-; and when Y is -N=, X is -O-; or a pharmaceutically acceptable salt thereof, optionally in conjunction with a compound of the formula II wherein R1 is halogen, hydrogen, lower alkyl or lower alkoxy; R2, R3 and R4 taken independently of each other are hydrogen, lower alkoxy or hydroxy-lower alkoxy and provided that R2, R3 and R4 taken independently of each other represent at least one oxygenated substituent; or R1, R2, R3 and R4 taken as an adjacent pair is methylenedioxy. The above active ingredient(s) can be conveniently applied in the form of pharmaceutical compositions comprising an effective amount of said active ingredient(s) and a pharmaceutically acceptable carrier for topical administration, e.g. in the form of gels, creams, lotions, ointments, powders, aerosols, troches and suppositories. Composition containing a compound of formula I or a salt thereof and a compound of formula II are novel per se, i.e. without regard to the nature of the pharmaceutical formulations containing same.