| 摘要 |
NEW MATERIAL:A bicyclooctane derivative expressed by formula I [X<1> is carboxyl or group of formula II (R<a> and R<b> are H, alkyl, cycloalkyl, benzyl or phenyl, etc.; R<a> and R<b> and N together form a heterocyclic ring); R<1> is H or OH; R<2> is H or R<1> and R<2> together form a single bond; R<3> is OH; R<4> is H or alkyl; R<5> is H, alkynyl, alkenyl, alkyl or cycloalkyl, etc.; Y is a group of formula III or IV (R<6> is H or alkyl)]. EXAMPLE:2beta-( 3'-Hydroxy-trans-1'-octenyl )-3alpha-hydroxy-7-( 2'-carboxymethoxyethyl)-cis-bicyclo[3,3,0]octane. USE:A stable antiulcer agent, remedy for arteriosclerosis, angina pectoris, preventing and treating agent for ischemic diseases of brains and hearts and carcinostatic agent. PREPARATION:A ketone derivative expressed by formula V (X<1> is X<2>, etc.) is reacted with a reducing agent or a compound expressed by the formula M-R<7> (M is Li or Mg-halo; R<7> is alkyl) in a solvent to afford the aimed compound expressed by formula I .
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