摘要 |
<p>Compounds of the formula
<CHEM>
and their pharmaceutically acceptable salts, wherein:
U is oxygen, sulfur or nitrogen substituted with hydrogen or alkyl having 1-4 carbon atoms;
n is zero or one;
W is carbonyl or hydroxymethylene;
R is hydrogen or alkyl having 1-4 carbon atoms;
X is hydrogen, chloro, bromo, iodo, alkyl having 1-4 carbon atoms, dimethyl or (CH2)mQ wherein m is 1 or 2 and Q is phenyl or halophenyl, with the proviso that when X is dimethyl, n is one;
Y is hydrogen, halo, nitro, trifluoromethyl, alkoxy having 1-4 carbon atoms or alkyl having 1-4 carbon atoms; and
Z is hydrogen, halo, nitro, trifluoromethyl, alkoxy having 1-4 carbon atoms or alkyl having 1-4 carbon atoms, with the proviso that if either Y or Z is nitro the other is hydrogen.
<??>The compounds are useful in the treatment of certain chronic complications arising from diabetes mellitus, such as diabetic cataracts, retinopathy and neuropathy. </p> |