摘要 |
<p>of the Invention The invention relates to the preparation of the 5Z-isomers of 2,3,4-trinor-1,5-inter-m-phenylene-prostacyclin derivatives of the formula < IMG > (I) wherein R1 is a hydrogen atom, a cation or a lower alkyl radical, R2 is hydrogen or methyl, A is a member of the group consisting of the radicals -CH2-CH2-, (trans)-CH=CH- and -C?C- and B is an alkyl radical or a cycloalkyl radical optionally substituted by a lower alkyl radical by isomerization of a compound of the formula < IMG > (IIE) wherein R2, A and B have the same meaning as above and R? is a lower alkyl or aralkyl radical,</p> |