| 摘要 |
The nitroimidazoles having general formula: <IMAGE> (I) wherein R represents alkyl C1-C5, hydroxyalkyl C1-C5, an alkylsulfonyl group, an aminoalkyl group, wherein the alkyl contains 1 to 5 carbon atoms and the amino group is the radical of a secundary or tertiary, linear or cyclic amine; R1 is -OH and R2 represents the group: <IMAGE> (II) the tert-butyl substituent -C(CH3) being in the 3, 4 or 6 position of the anisole ring or R1 and R2 both represent the above indicated group (II), are endowed with activity against pathogenic protozoa and bacteria, particularly as regards Trichomonas vaginalis. The subject compounds are prepared by reacting a halo-magnesium derivative of tert-butyl-4-hydroxy-anisole and 5-nitro, 1-R substituted, 2-formyl-imidazole.
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